Chowdhury, Ankita Dutta and Roy, Somenath (2026) Electrocatalytic Detection of Epinephrine using an Engineered 2D Carbon/ Metal-Oxide Disposable Sensor in a Point-of-Care setting. In: 2D MatTech Global: Fundamentals to. Applications , 24th – 26th. June, 2026, IIT Indore, M.P.. (Submitted)

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Abstract

Epinephrine is a biologically important catecholamine that functions as both a neurotransmitter and hormone, and its reliable determination is important for clinical diagnosis, stress-related physiology, and biochemical monitoring. In this work, an engineered 2D carbon/metal-oxide interface was developed as an electrochemical platform for the sensitive detection of epinephrine in simulated urine matrix. The modified electrode produced a distinct anodic peak for epinephrine oxidation, indicating favourable charge transfer at the electrode-electrolyte interface. The cuprous spinel-reduced graphene oxide (CuM2O4-rGO, M=Co, Cr, Mn) nanocomposites were synthesized via one pot co precipitation technique and thoroughly characterized using sophisticated characterization techniques such as XRD, XPS, Transmission Electron Microscopy, Raman Spectroscopy etc. spectroscopy to establish structure–property–function correlations relevant to electrocatalytic sensing. An overall comparative study was also well established between the spinel compounds and integration of the most sensitive nanocomposite on indigenously fabricated screen-printed electrodes showed a broad detection range from 30 nM to 100 µM, with a linear calibration response within the studied concentration window. The lower limit of detection was estimated to be 26 nM, and the response was obtained within less than 1 min. As a step towards translational deployment, the fabricated electrodes were integrated with an ultraportable, IoT enabled, miniaturized pocket friendly device that can selectively detect neurotransmitters from a drop of urine sample in less than a minute, without the help of trained clinicians and operators. The results appear on the patient’s smartphone through a customized application software which can be easily shared with clinicians, thereby bridging functional material design to real-world point-of-care neurodiagnostic applications. The present study thus demonstrates that an interface-engineered 2D carbon/metal-oxide interface electrode can serve as a simple, rapid, and sensitive disposable platform for electrochemical detection of catecholamine biomarkers. Keywords: electrocatalysis, catecholamines, 2D Carbon/Metal-Oxide, point-of-care

Item Type:	Conference or Workshop Item (Lecture)
Subjects:	Electronics
Divisions:	Sensor and Actuator
Depositing User:	Ms Upasana Sahu
Date Deposited:	23 Sep 2026 09:06
Last Modified:	23 Sep 2026 09:06
URI:	https://cgcri.csircentral.net/id/eprint/5836

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