Dey, Arjun and Nandi, Samit Kumar and Kundu, Biswanath and Kumar, Chandrasekhar and Mukherjee, Prasenjit and Roy, Subhasis and Mukhopadhyay, Anoop Kumar and Sinha, Mithlesh Kumar and Basu, Debabrata (2011) Evaluation of hydroxyapatite and beta-tri calcium phosphate microplasma spray coated pin intra-medullary for bone repair in a rabbit model. Ceramics International, 37 (4). pp. 1377-1391. ISSN 0272-8842

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Abstract

Here we report a comparative study of the healing kinetics of surgically created artificial defects in the tibia of New Zealand white rabbits. Comparison of the healing kinetics was made for uncoated conventional SS316L intramedullary pins, and the same pins with microplasma sprayed (MIPS) pure hydroxyapatite (HAp) and beta-tri calcium phosphate (beta-TCP) coatings. After thorough material characterizations including XRD, FTIR, SEM, etc., MIPS coated pins were implanted to such animals. Serum biochemistry, radiology and fluorochrome labelling were used to evaluate the comparative healing kinetics of these implants in vivo. In comparison to those of the uncoated pins, the pins coated with both MIPS HAp and beta-TCP showed significant increment of alkaline phosphatase up to 15th postoperative day, insignificant changes in serum phosphorus and calcium with uneventful healing of bone defect. There was development of Havarsian canals and well-defined peripherally placed osteoblasts along with evidence of angiogenesis and comparatively more new bone formation in the defect site. On a comparative scale, the performance of the beta-TCP coated intramedullary pins was much better than that of the pure HAp coated pins than the uncoated intramedullary pins. (C) 2011 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

Item Type:	Article
Additional Information:	Hydroxyapatite; beta-Tri calcium phosphate; Microplasma spraying; In vivo animal trial; Intramedullar pinning; Bone defects healing
Subjects:	Microstructure and Characterization
Divisions:	UNSPECIFIED
Depositing User:	Bidhan Chaudhuri
Date Deposited:	16 Jan 2012 12:05
Last Modified:	31 Jan 2013 11:31
URI:	http://cgcri.csircentral.net/id/eprint/90

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