Kayal, Pallabi and Jana, Sonali and Datta, Pradyot and Das, Himanka and Kundu, Biswanath and Nandi, Samit Kumar (2023) Microfibers of fish waste-derived collagen and ion-doped bioactive glass in stimulating the healing sequences in full-thickness cutaneous burn injury. Journal of Drug Delivery Science and Technology, 83. Art No-104429. ISSN 1773-2247

Full text not available from this repository. (Request a copy)

Abstract

Burns are extremely debilitating, requiring prompt and prolonged therapeutic protocol for ensuring healing and survivability. For efficient burn coverage and controlling the inflammation, and infection as well as triggering the overall wound healing cascade there is an incessant demand to generate a dressing material as an adjunct burn therapy. We fabricated five different types of microfibrous mats having bioactive properties using pristine fish collagen and in combination with bioactive glass/ion-doped bioactive glass. All the mats were cytocompatible with human dermal fibroblasts supporting cellular adherence, proliferation, and viability. The mats also ensured enhanced wound healing in full-thickness cutaneous burns in the rabbit model. The fish collagen/ion-doped microfibrous mats in particular showed a better response in terms of neovascularization, re-epithelialization, and ECM component deposition such as collagen and elastin. The wounds treated with Fcol/CuCoBG mat demonstrated a significantly (p < 0.01) greater regeneration of blood vessels compared to all the other groups. Such features indicate the intrinsic bioactive roles of fish collagen and ion-doped bioactive glass towards favorable regeneration and closure of burn wounds thereby establishing its potency in burn care.

Item Type:	Article
Subjects:	Engineering Materials
Divisions:	Bioceramics & Coating
Depositing User:	Bidhan Chaudhuri
Date Deposited:	10 Oct 2023 07:21
Last Modified:	10 Oct 2023 07:21
URI:	http://cgcri.csircentral.net/id/eprint/5585

Actions (login required)

View Item