Elshazly, Noha Eltantawy Ahmed Baiomy and Saad, Manal and Khalil, Abdelaziz and Patruno, Marco and Chakraborty, Jui and ElBackly, Rania and Hamdy, Ayat and Marei, Mona (2022) Regenerative properties of topically applied 3D electrospun nanoscaled bioactive glass fibers on diabetic oral mucosal defects. Tissue Engineering Part A, 28 (1). S119-S120. ISSN 1937-3341

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Abstract

Diabetes triggers chronic inflammation, declines the antibacterial action and angiogenesis leading to protracted wound healing. Bioactive glass manifested high regenerative efficacy when used in bone regeneration (1). This study aimed to assess the regenerative efficacy of novel bioactive glass nanofibers (BGnf) on surgically created alveolar mucosal wounds of the diabetic rabbit model. Glass nanofibers(500‐900nm):(1–2mol% of B2O3, 68–69 mol% of SiO2, and 29–30 mol% of CaO) were synthesized via the sol‐gel technique followed by electrospinning of the glass/polymer sol and heat‐treatment of fibers at 700C(2). Fibers analysis broadcasted its amorphous, cross‐linked structure and bioactivity. Following that, 12 healthy New Zealand rabbits were successfully subjected to chemical induction of type I diabetes. Two weeks after diabetes confirmation, two groups of bilateral elliptical maxillary mucosal defects (10 * 3.5 mm) were created. The defects of the experimental group were grafted with BGnf(n = 12), while the other group was the control(n = 12). To evaluate fibers regenerative efficacy, three different assessments (clinical, histological, and immune‐histochemical) were performed at 1, 2 and 3 weeks' time interval(2). After 1 week, BGnf treated wounds showed complete wound regeneration with significantly high‐level VEGF (14.08 ± 3.88%) and collagen I% (6.12 ± 0.49%) expression. Contrariwise, the control group showed suppurative exudates with inflammatory cell infiltration at lamina propria and lower VEGF(3.92 ± 0.222%) and collagen I(3.88 ± 1.934%) expression. After 3 weeks, VEGF and collagen I of BGnf group also recorded a higher expression than the control group. In conclusion, BGnf stimulates in‐ situ soft tissue regeneration, neovascularization and antibacterial action in the wet oral environment in diabetic patients.

Item Type:	Article
Subjects:	Engineering Materials
Divisions:	Bioceramics & Coating
Depositing User:	Bidhan Chaudhuri
Date Deposited:	29 Aug 2023 10:25
Last Modified:	29 Aug 2023 10:25
URI:	http://cgcri.csircentral.net/id/eprint/5446

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