Roy, Payal and Saha, Rupam and Chakraborty, Jui (2023) A novel composition of bioactive glass with potent haemostatic action and antibacterial competence. Ceramics International, 49 (4). pp. 6389-6400. ISSN 0272-8842

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Abstract

Haemorrhagic bleeding is a crucial area of concern related to military as well as civilian trauma. In recent years, bioactive glass is gaining attention in a number of healthcare applications, including haemostasis. Herewith, we report a unique composition of bioactive glass, 70 SiO2: (30-x-y) CaO: x.Al2O3: y.ZnO, where x = 10–18 mole% and y = 0–8 mole%, (Al-BAG) exhibiting haemostatic property as well as antibacterial activity. The as-prepared glass was characterized using XRD, SEM-EDX, FTIR and TG-DSC along with in-vitro degradation study and biological studies e.g., cytocompatibility, haemocompatibility, in-vitro thrombus formation, in-vitro blood absorption capacity, blood coagulation assays (PT, aPTT), in-vitro antibacterial assay against Staph. aureus as well as in-vivo acute dermal toxicity followed by histopathological analysis) and in-vivo haemostasis efficacy were undertaken. The novel bioactive glass composition exhibits promises to be an efficient haemostatic agent with antibacterial activity.

Item Type:	Article
Subjects:	Engineering Materials
Divisions:	Bioceramics & Coating
Depositing User:	Bidhan Chaudhuri
Date Deposited:	22 Feb 2023 11:50
Last Modified:	22 Feb 2023 11:50
URI:	http://cgcri.csircentral.net/id/eprint/5397

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