Agarwal, Swarnima and Saha, Shreya and Balla, V K and Pal, Aniruddha and Barui , Ananya and Bodhak , Subhadip
(2020)
Current Developments in 3D Bioprinting for Tissue and Organ Regeneration–A Review.
Frontiers in Mechanical Engineering, 6.
Art No- 589171.
ISSN 2297-3079
Abstract
Thefield of Tissue engineering and regenerative medicine that work toward creatingfunctional tissue-constructs mimicking native tissue for repair and/or replacement ofdamaged tissues or whole organs have evolved rapidly over the past few decades.However, traditional tissue engineering approaches comprising of scaffolds, growthfactors and cells showed limited success in fabrication of complex 3D shapes andinvivoorgan regeneration leading to their non-feasibility for clinical applications from alogistical and economical viewpoint. In this regard, 3D bioprinting, which is an extendedapplication of additive manufacturing is now being explored for tissue engineering andregenerative medicine as it involves the top-down approach of building the complex tissuein a layer by layer fashion, thereby producing precise geometries due to controlled nature ofmatter deposition with the help of anatomically accurate 3D models of the tissue generatedby computer graphics. Here, we aim to provide a comprehensive review of the 3Dbioprinting technology along with associated 3D bioprinting strategies including ink-jetprinting, extrusion printing, stereolithography and laser assisted bioprinting techniques.We then focus on the applications of 3D bioprinting technology on construction of variousrepresentative tissue and organs, including skin, cardiac, bone and cartilage etc. Wefurther attempt to highlight the steps involved in each of those tissues/organs printing anddiscuss on the associated technological requirements based on the available reports fromrecent literature. Wefinally conclude with current challenges with 3D bioprintingtechnology along with potential solution for future technological advancement ofefficient and cost-effective 3D bioprinting methods.
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