Soundrapandian, Chidambaram and Basu, Debabrata and Sa, Biswanath and Datta, Someswar (2011) Local drug delivery system for the treatment of osteomyelitis: In vitro evaluation. Drug Development and Industrial Pharmacy, 37 (5). pp. 538-546. ISSN 0363-9045

PDF - Published Version Restricted to Registered users only Download (1020Kb) | Request a copy

Abstract

Local antimicrobial delivery is a potential area of research conceptualized to provide alternative and better methods of treatment for cases, as osteomyelitis where avascular zones prevent the delivery of drugs from conventional routes of administration. Drug-loaded polymers and calcium phosphates as hydroxyapatites have been tried earlier. Bioactive glasses are bone-filling materials used for space management in orthopedic and dental surgery. A new bioactive glass (SSS2) was synthesized and fabricated into porous scaffold with a view to provide prolonged local delivery of gatifloxacin and fluconazole as suitable for the treatment of osteomyelitis. The new SSS2 was characterized by Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses. In addition, the bioactivity of the SSS2 glass and resulting scaffold was examined by in vitro acellular method and ascertained by FTIR and XRD. The pore size distribution was analysed by mercury intrusion porosimetry and the release of drugs from scaffolds were studied in vitro. The glass and the resulting scaffolds were bioactive indicating that they can bond with bone in vivo. The scaffolds were porous with pores predominantly in the range of 10-60 mu m, released the drugs effectively for 6 weeks and deemed suitable for local delivery of drugs to treat osteomyelitis.

Item Type:	Article
Uncontrolled Keywords:	Drug release; chitosan; bone infection; bioceramic; composite; bone implant; ceramic implants; gatifloxacin; skeletal drug delivery; fluconazole
Subjects:	Processing Science
Divisions:	Bioceramics & Coating
Depositing User:	Bidhan Chaudhuri
Date Deposited:	25 Jan 2012 06:35
Last Modified:	30 Mar 2016 05:45
URI:	http://cgcri.csircentral.net/id/eprint/429

Actions (login required)

View Item