Soundrapandian, Chidambaram and Bharati, Sanghamitra and Basu, Debabrata and Datta, Someswar (2011) Studies on novel bioactive glasses and bioactive glass-nano-HAp composites suitable for coating on metallic implants. Ceramics International, 37 (3). pp. 759-769. ISSN 0272-8842

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Abstract

A series of novel zinc oxide (ZnO) containing bioactive glass compositions in SiO(2)-Na(2)O-CaO-P(2)O5 system and composite with hydroxyapatite (HAp) nano-particles were developed and applied as coating on Ti-6Al-4V substrates. The bioactive glasses and their composites were also processed to yield dense scaffolds, porous scaffolds and porous bone filler materials. The coating materials and the coatings were characterized and evaluated by different in vitro techniques to establish their superior mechanical properties. The cytotoxicity test of the coating material, porous and dense scaffolds and coated specimens showed non-cytotoxicity, biocompatibility and promising in vitro bioactivity for all tested samples. The dissolution behaviour studies of the bioactive glasses and the composites in simulated body fluid showed promising in vitro release pattern and bioactivity for all tested samples. Addition of nanosized HAp improves mechanical properties of the bioactive glass coating without affecting the in vitro bioactivity. (C) 2010 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	Nanocomposites; Glass ceramics; Apatite; Biomedical applications
Subjects:	Glass
Divisions:	Bioceramics & Coating
Depositing User:	Bidhan Chaudhuri
Date Deposited:	25 Jan 2012 06:35
Last Modified:	25 Feb 2013 08:41
URI:	http://cgcri.csircentral.net/id/eprint/428

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