Bhattacharya, Rupnarayan and Kundu, Biswanath and Nandi, Samit Kumar and Basu, Debabrata (2013) Systematic approach to treat chronic osteomyelitis through localized drug delivery system: Bench to bed side. Materials Science and Engineering: C Materials for Biological Applications, 33 (7). pp. 3986-3993. ISSN 0928-4931

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Abstract

Chronic osteomyelitis is a challenging setback to the orthopedic surgeons in deciding an optimal therapeutic strategy. Conversely, patients feel frustrated of the therapeutic outcomes and development of adverse drug effects, if any. Present investigation deals with extensive approach incorporating in vivo animal experimentation and human application to treat chronic osteomyelitis, using antibiotic loaded porous hydroxyapatite scaffolds. Micro- to macro-porous hydroxyapatite scaffolds impregnated with antibiotic ceftriaxone-sulbactam sodium (CFS) were fabricated and subsequently evaluated by in vivo animal model after developing osteomyelitis in rabbit tibia. Finally 10 nos. of human osteomyelitis patients involving long bone and mandible were studied for histopathology, radiology, pus culture, 3D CT etc. up to 8-18 months post-operatively. It was established up to animal trial stage that 50N50H samples [with 50-55% porosity, average pore size 110 mu m, higher interconnectivity (10-100 mu m), and moderately high drug adsorption efficiency (50%)] showed efficient drug release up to 42 days than parenteral group based on infection eradication and new bone formation. In vivo human bone showed gradual evidence of new bone formation and fracture union with organized callus without recurrence of infection even after 8 months. This may be a new, alternative, cost effective and ideal therapeutic strategy for chronic osteomyelitis treatment in human patients. (C) 2013 Elsevier B.V. All rights reserved.

Item Type:	Article
Subjects:	Processing Science
Divisions:	Bioceramics & Coating
Depositing User:	Bidhan Chaudhuri
Date Deposited:	05 Feb 2014 12:21
Last Modified:	12 Mar 2016 14:31
URI:	http://cgcri.csircentral.net/id/eprint/2481

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