Chakraborty, Manjusha and Dasgupta, Sudip and Soundrapandian, Chidambaram and Chakraborty, Jui and Ghosh, Swapankumar and Mitra, Manoj K. and Basu, Debabrata (2011) Methotrexate intercalated ZnAl-layered double hydroxide. Journal of Solid State Chemistry, 184 (9). pp. 2439-2445. ISSN 0022-4596

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The anticancerous drug methotrexate (MTX) has been intercalated into an ZnAl-layered double hydroxide (LDH) using an anion exchange technique to produce LDH-MTX hybrids having particle sizes in the range of 100-300 nm. X-ray diffraction studies revealed increases in the basal spacings of ZnAl-LDH-MTX hybrid on MTX intercalation. This was corroborated by the transmission electron micrographs, which showed an increase in average interlayer spacing from 8.9 angstrom in pristine LDH to 21.3 angstrom in LDH-MTX hybrid. Thermogravimetric analyses showed an increase in the decomposition temperature for the MTX molecule in the LDH-MTX hybrid indicating enhanced thermal stability of the drug molecule in the LDH nanovehicle. The cumulative release profile of MIX from ZnAl-LDH-MTX hybrids in phosphate buffer saline (PBS) at pH 7.4 was successfully sustained for 48 h following Rigter-Peppas model release kinetics via diffusion. (C) 2011 Elsevier Inc. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Layered doublehydroxides; Methotrexate; Intercalation; Hybrids Release kinetics
Subjects: Processing Science
Depositing User: Bidhan Chaudhuri
Date Deposited: 16 Jan 2012 12:04
Last Modified: 25 Feb 2013 07:55

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