Nandi, S K and Roy, Samudra and Mukherjee, P and Kundu, Biswanath and De, D K and Basu, Debabrata (2010) Orthopaedic applications of bone graft & graft substitutes: a review. Indian Journal of Medical Reseach, 132 (1). pp. 15-30. ISSN 0971-5916

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Treatment of delayed union, malunion, and nonunion is a challenge to the orthopaedic surgeons in veterinary and human fields. Apart from restoration of alignment and stable fixation, in many cases adjunctive measures such as bone-grafting or use of bone-graft substitutes are of paramount importance. Bone-graft materials usually have one or more components: an osteoconductive matrix, which acts as scaffold to new bone growth; osteoinductive proteins, which support mitogenesis of undifferentiated cells; and osteogenic cells, which are capable of forming bone in the appropriate environment. Autologous bone remains the ``gold standard'' for stimulating bone repair and regeneration, but its availability may be limited and the procedure to harvest the material is associated with complications. Bone-graft substitutes can either substitute autologous bone graft or expand an existing amount of autologous bone graft. We review the currently available bone graft and graft substitutes for the novel therapeutic approaches in clinical setting of orthopaedic surgery.

Item Type: Article
Uncontrolled Keywords: Bone graft; Orthopaedic surgery; Osteoconductive; Osteoinductive; Osteogenic graft substitute
Subjects: Engineering Materials
Depositing User: Bidhan Chaudhuri
Date Deposited: 15 Feb 2012 07:05
Last Modified: 28 Mar 2018 09:35

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