Chakraborty, Anustup (2024) Effect of Compositional Modification of Bioactive Glasses Towards High Temperature Processability and In Vitro Biological Properties. PhD thesis, CSIR CGCRI and AcSIR.
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This study aimed to develop bioactive glasses with enhanced thermal stability and biocompatibility for bone tissue engineering applications. By strategically incorporating boron oxide (B2O3) and adjusting the CaO/Na2O ratio, glasses were successfully formulated with superior thermal processability, antibacterial properties, and biomineralization capabilities. A comprehensive composition-structure-property relationship was established, revealing that B2O3 addition strengthens the glass network, leading to improved thermal stability (<150 °C) while retaining fast bioactivity (1 day). Additionally, increasing CaO content while maintaining an optimal SiO2/B2O3 ratio resulted in enhanced mechanical properties and a closer match (α50-300 = 8.5 × 10-6 /°C) to the thermal expansion coefficient of titanium-based implants. Moreover, these glasses with modified compositions demonstrated exceptional in vitro biological performance, promoting cell growth and inhibiting antibacterial properties. The optimized glass compositions were further utilized for fabrication of amorphous tissue engineering constructs such as scaffold and coating highlighting the potential of such compositions for tissue engineering applications. Crystallization kinetics studies guided the development of amorphous bioactive glass scaffolds through controlled sintering processes. Furthermore, a novel bioactive glass coating was successfully fabricated on titanium-based implants. This coating exhibited superior biocompatibility and antibacterial properties compared to conventional bioactive glass (45S5) coatings. Overall, this study offers valuable insights for the design and fabrication of tailored bioactive glass-based materials while also proposing optimized formulations for bioactive glass-based scaffold and coating for bone tissue engineering applications.
| Item Type: | Thesis (PhD) |
|---|---|
| Additional Information: | Supervisor(s): Dr. Kaushik Biswas (Supervisor) & Dr. Subhadip Bodhak (Co-supervisor) |
| Subjects: | Glass |
| Divisions: | Glass |
| Depositing User: | Ms Upasana Sahu |
| Date Deposited: | 01 Sep 2025 11:28 |
| Last Modified: | 01 Sep 2025 11:28 |
| URI: | http://cgcri.csircentral.net/id/eprint/5748 |
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