Roy, Payal and Saha, Rupam and Saha, Suman and Dattaray, Debolina and Mandal, Tapan Kumar and ElShazly, Noha and Marei, Mona K and Chakraborty, Jui (2023) Facile synthesis of electrospun antibacterial bioactive glass based micronanofibre (ABGmnf) for exalted wound healing: In vitro and in vivo studies. Materials Chemistry and Physics, 305. Art No-127874. ISSN 0254-0584

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Recently, bioactive glass has shown an incredible potential to address the assortment of chronic wounds including diabetic and venous ulcers. In this regard, the textural properties of bioactive glass (BG)-based micronanofibre, which are analogous to the fibrin clot that aggregates platelets, provide advantages that support the coagulation cascade and subsequent soft tissue regeneration by providing mechanical support and a source of various therapeutic ions. In this correspondence, we synthesized a binary composition comprising (70-x) mol% SiO2, (30-y) mol% CaO, 1 < x < 5 mol% B2O3 and 0.001< y < 0.1mol% Ag2O composition (ABGmnf) via sol-gel method followed by fabrication of the electrospun fibres, and state-of-art characterizations, XRD, FTIR, and FESEM-EDXalong with biological studies including in-vitro cytocompatibility, 2D wound healing, antibacterial activities by determination of minimum inhibitory concentration (MIC). In addition, the concentration of proinflammatory cytokines (TNF-a and IL-6) and various hematological, biochemical, and histopathological parameters were used to establish the in vivo biocompatibility. The in vivo wound healing assay, which demonstrated rapid wound closure, was then examined. ABGmnf's excellent cyto-and biocompatibility could be demonstrated by the above findings alongwith the lack of host-material interaction, as well.

Item Type: Article
Subjects: Glass
Divisions: Bioceramics &amp; Coating
Depositing User: Bidhan Chaudhuri
Date Deposited: 13 Oct 2023 07:22
Last Modified: 13 Oct 2023 07:22

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