Dey, Tanoy Kumar and Tombelli, Sara and Biswas, Palas and Giannetti, Ambra and Basumallick, Nandini and Baldini, Francesco and Bandyopadhyay, Somnath and Trono, Cosimo (2021) Label-free immunosensing by long period fiber gratings at the lowest order cladding mode and near turn around point. Optics and Laser Technology, 142. Art No-107194. ISSN 0030-3992

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A long period fiber grating has been fabricated by combining two sensitivity enhancement techniques, the turn around point (TAP) and the maximum enhancement of the evanescent field by obtaining the lowest order cladding mode (LP0,2 cladding mode). A label-free immunoglobulin G/anti immunoglobulin G (IgG/anti-IgG) immunoassay in serum has been performed with the sensor inside a thermostated closed flow cell. Real time kinetics of the IgG and anti-IgG binding has been monitored and evaluated. By measuring the dual peak resonance of the LP0,2 cladding mode, a limit of detection of 0.16 ng/ml (1.06 pM) for anti-IgG has been achieved.

Item Type: Article
Subjects: Processing Science
Divisions: Fiber Optics and Photonics
Depositing User: Bidhan Chaudhuri
Date Deposited: 22 Dec 2021 10:08
Last Modified: 22 Dec 2021 10:08

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