Das, Mitun and Sharabani-Yosef, Orna and Eliaz, Noam and Mandler, Daniel (2021) Hydrogel-integrated 3D-printed poly(lactic acid) scaffolds for bone tissue engineering. Journal of Materials Research, 36 (19, SI). pp. 3833-3842. ISSN 0884-2914

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Abstract

There is currently a high demand for synthetic biodegradable scaffolds with enhanced osteogenic and angiogenic performance for the regeneration of large-size bone defects. Here, hybrid scaffolds were prepared by integrating either alginate or alginate-bioglass composite hydrogels with a 3D-printed poly(lactic acid) (PLA) porous structure. The as-deposited PLA scaffolds were surface treated with polyacrylic acid (PAA), which significantly enhanced the PLA scaffold's wettability. The surface-modified PLA scaffolds integrated well with hydrogels and provided shape and mechanical rigidity to the hydrogel. In phosphate-buffered saline, the lowest weight loss during 21-days immersion was measured for the PLA scaffold, while alginate-bioglass scaffolds lost similar to 1.9% weight during the first 7 days of immersion. In vitro cytocompatibility tests indicated good cell viability and cell proliferation on the scaffolds. The bioglass-containing hybrid scaffold promoted osteogenic differentiation and calcium mineralization. The excellent biocompatibility, good mechanical stability of the hydrogel, and shape retention of the novel hybrid scaffolds with cell-laden alginate could make them attractive for large bone regeneration.

Item Type:	Article
Subjects:	Engineering Materials
Divisions:	Bioceramics & Coating
Depositing User:	Bidhan Chaudhuri
Date Deposited:	14 Dec 2021 07:03
Last Modified:	14 Dec 2021 07:03
URI:	http://cgcri.csircentral.net/id/eprint/5230

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