Sarkar, Kaushik and Rahaman, Mofizur and Agarwal, Swarnima and Bodhak, Subhadip and Halder, Samar and Nandi, Samit Kumar and Roy, Mangal (2020) Degradability and in vivo biocompatibility of doped magnesium phosphate bioceramic scaffolds. Materials Letters, 259. Art No-126892. ISSN 0167-577X

PDF - Submitted Version Restricted to Registered users only Download (2270Kb) | Request a copy

Abstract

In the present study, degradability and in vivo biocompatibility of doped magnesium phosphate (MgP) scaffolds were evaluated. 0.5 wt% Zn, 0.5 wt% Si, and 2 wt% Sr doped MgP scaffolds were prepared with up to 47% porosity. Zn doped MgP scaffolds showed nearly 13% weight loss when immersed in SBF for 8 weeks whereas least degradation was noticed for Sr doped samples. In vitro cytocompatibility study, using MC3T3-E1, showed significantly higher cell proliferation at day 5 in a composition independent manner. When implanted in rabbit femur, micro-CT (mu-CT) results showed extensive degradation for Zn doped MgP scaffolds after 2 months while significant bone growth was noticed for both Si and Sr doped scaffolds. (C) 2019 Elsevier B.V. All rights reserved.

Item Type:	Article
Subjects:	Engineering Materials
Divisions:	UNSPECIFIED
Depositing User:	Bidhan Chaudhuri
Date Deposited:	08 Feb 2021 07:59
Last Modified:	08 Feb 2021 07:59
URI:	http://cgcri.csircentral.net/id/eprint/4967

Actions (login required)

View Item