Lalzawmliana, V and Anand, Akrity and Kumar, Vinod and Das, Piyali and Devi, K Bavya and Mukherjee, Jayanta and Maji, Asit Kumar and Kundu, Biswanath and Roy, Mangal and Nandi, Samit Kumar (2019) Potential of growth factor incorporated mesoporous bioactive glass for in vivo bone regeneration. Journal of the Mechanical Behavior of Biomedical Materials, 91. pp. 182-192. ISSN 1751-6161

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Mesoporous bioactive glass (MBG) has drawn much attention due to its superior surface texture, porosity and bioactive characteristics. Aim of the present study is to synthesize MBG using different surfactants, viz., hexadecyltrimethylamonium(CTAB) (M1), poly-ethylene glycol (PEG) (M2) and pluronic P123 (M3); bioactivity study; and to understand their bone regeneration efficacy in combination with insulin-like growth factors (IGF-1) in animal bone defect model. SBF study revealed the formation of calcium carbonate (CaCO 3 ) and hydroxyapatite (HAp) phase over 14 days. Formation of apatite layer was further confirmed by FTIR, FESEM and EDX analysis. M1 and M2 showed improved crystallinity, while M3 showed slightly decrease in crystalline peak of CaCO3 and enhanced HAp phase. More Ca-P layer formed in M1 and M2 supported the in vivo experiments subsequently. Degree of new bone formation for all MBGs were high, i.e., M1 (80.7 +/- 2.9%), M2 (74.4 +/- 2.4%) and M3 (70.1 +/- 1.9%) compared to BG (66.9 +/- 1.8%). In vivo results indicated that the materials were non-toxic, biodegradable, biocompatible, and is suitable as bone replacement materials. Thus, we concluded that growth factor loaded MBG is a promising candidate for bone tissue engineering application.

Item Type: Article
Subjects: Engineering Materials
Divisions: Bioceramics & Coating
Depositing User: Bidhan Chaudhuri
Date Deposited: 15 Nov 2019 07:42
Last Modified: 15 Nov 2019 07:42

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