Khatua, Chandra and Sengupta, Somoshree and Kundu, Biswanath and Bhattacharya, Dipten and Balla, V K (2019) Enhanced strength, in vitro bone cell differentiation and mineralization of injectable bone cement reinforced with multiferroic particles. Materials & Design, 167. Art No-107628. ISSN 0261-3069

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Self-setting calcium sulphate hemihydrate (CSH) composites were prepared by reinforcing with BiFeO3 (BF, a multiferroic material) with an aim to induce in situ charge generating capacity and increase its strength. CSH-BF composites (0-15 wt%BF), prepared by ball-milling, were evaluated in terms of setting and injectability, compressive strength, in vitro degradation, electrical/magnetic properties. Compressive strength of CSH-BF composites increased with BF concentration and up to 3-fold increase was observed compared to pure-CSH. Injectability and setting time of these composites were comparable to that of standard bone cements. In vitro degradation studies revealed similar to 27-33% degradation with good apatite precipitation on these composites. Remanant polarization of these composites varied between 0.056 and 0.251 mu C/cm(2). The composites with BF <= 5 wt% exhibited 200-375% increase in the cell viability with 200mT magnetic treatment. Osteoblast differentiation experiments showed high and rapid production of Alkaline Phosphatase followed by accelerated bone mineralization on the composites compared to pure-CSH. Electrical stimuli (remanant polarization) and its coupling during magnetic field treatment are responsible for enhanced bone-cell differentiation and mineralization on CSH-BF composites. Our results show that BF reinforcement of CSH not only improves its strength but also impart charge generating capacity, which can be effectively utilized to accelerate tissue healing or regeneration. (C) 2019 The Authors. Published by Elsevier Ltd.

Item Type: Article
Subjects: Engineering Materials
Divisions: Bioceramics &amp; Coating
Depositing User: Bidhan Chaudhuri
Date Deposited: 14 Nov 2019 09:36
Last Modified: 14 Nov 2019 09:36

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