Acharya, Rituparna and Saha, Suman and Ray, Sayantan and Chakraborty, Jui (2017) Nanoparticulate Immunotherapy: An Intelligent Way to Tailor Make Our Defense System. In: Particulate Technology for Delivery of Therapeutics. Springer, Singapore, pp. 419-451. ISBN 978-981-10-3646-0

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The term ‘Immunotherapy’ refers to a complex process to combat cancer, infections, and other diseases by suppressing, enhancing, or inducing the immune response to the host. The major limitation of the therapy is its inability to produce enough trained immune cells in the system. Currently, researchers have pursued immunotherapy as a treatment protocol, based on training the host’s immune system to fight with the diseases. Immune response can be activated by dendritic cell based, T cell adoptive, autologous immune enhancement or genetically engineered T cell or can be suppressed by some drugs that are very much useful in organ transplantation. Immune tolerance refers to a process by which body will not launch an attack to its own cells but helps to stop attacks to its tissue, simultaneously, that occurs in autoimmune diseases, generally. In allergic conditions, immunotherapy is the only treatment option available, in which body can change or modify the immune response by reducing allergen sensitivity. In case of biological application, macro-size possesses numerous drawbacks on account of the smaller size of cellular compartment. Thus advance drug delivery system comprising nanoparticles encapsulating immunologically active compound holds great potential for target specific immunotherapy, in general. Hence, nanotechnology-based immunomodulatory drugs and vaccines help in the improvement in the field of immunotherapy, for the immunological diseases.

Item Type: Book Section
Subjects: Engineering Materials
Divisions: Bioceramics & Coating
Depositing User: Bidhan Chaudhuri
Date Deposited: 24 Oct 2017 11:08
Last Modified: 24 Oct 2017 11:08

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