Nandi, Samit Kumar and Bandyopadhyay, Samiran and Das, Piyali and Samanta, Indranil and Mukherjee, Prasenjit and Roy, Subhasis and Kundu, Biswanath (2016) Understanding osteomyelitis and its treatment through local drug delivery system. Biotechnology Advances, 34 (8). pp. 1305-1317. ISSN 0734-9750

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Chronic osteomyelitis is a major challenge in bone surgery. Conventional use of antibiotics is not an effective way to control the malaise due to so many reasons. Determination of optimal treatment strategy becomes difficult for the orthopaedic surgeons and as a consequence, the patients suffer not only from therapeutic failure but also due to adverse side effects of antibiotics and financial loss due to additional stay at hospitals. A wide application of carrier systems, as a medium for local delivery of antibiotics, is being used experimentally and clinically for the treatment of osteomyelitis. This kind of delivery system provides sustained higher concentration of antibiotics at the infection site with reduced possibility of toxicity. This review highlight etiology and pathophysiology of osteomyelitis, current therapeutic options with their limitations, and potentiality of biomaterial based carrier materials impregnated with antibiotics as local delivery approach. (C) 2016 Elsevier Inc. All rights reserved.

Item Type: Article
Subjects: Engineering Materials
Divisions: Bioceramics & Coating
Depositing User: Bidhan Chaudhuri
Date Deposited: 25 Jan 2017 12:40
Last Modified: 25 Jan 2017 12:40

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