Chakravarty, Amrita and Bhowmik, Koushik and De, Goutam and Mukherjee, Arnab (2015) Synthesis of amine functionalized graphite nanosheets and their water-soluble derivative for drug loading and controlled release. New Journal of Chemistry, 39 (4). pp. 2451-2458. ISSN 1144-0546

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A facile route to synthesize amine (–NH2) functionalized graphite nanosheets (AFGNS) by 2-step controlled chemical modification of microcrystalline graphite is described. The method begins with nitration by mixed acid (HNO3 : H2SO4 in 1 : 1 v/v ratio), followed by reduction with Na2S to form AFGNS. The AFGNS was reacted with carboxylic acid-terminated polyethylene glycol (PEG) chains (MeO–mPEG–COOH, MW = 5000 Da) in the presence of a carbodiimide coupling agent to obtain a water-soluble PEGylated AFGNS (P-AFGNS) composite. Anticancer drug doxorubicin (DOX) was loaded on this composite with a loading capacity of 0.296 mg mg−1 for an initial concentration of 0.232 mg mL−1 DOX and 0.136 mg mL−1 of P-AFGNS and the release of DOX from this water-soluble DOX loaded P-AFGNS composite at two different temperatures was found to be strongly pH dependent.

Item Type: Article
Subjects: Engineering Materials
Divisions: Nano-Structured Materials
Depositing User: Bidhan Chaudhuri
Date Deposited: 10 Sep 2015 05:05
Last Modified: 08 Feb 2017 09:27

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